ACSS1 (Acetyl-K642) Rabbit pAb

ACSS1 (acyl-CoA synthetase short-chain family member 1), also known as ACAS2L or AceCS2L, is a 689 amino acid protein that localizes to the mitochondrial matrix and belongs to the ATP-dependent AMP-binding enzyme family. Functioning primarily as a cardiac enzyme, ACSS1 catalyzes the ATP-dependent conversion of acetate and CoA (coenzyme A) to acetyl-CoA, which is then utilized for the oxidation of acetate within the tricarboxylic acid cycle. ACSS1 is expressed as two alternatively spliced isoforms and is encoded by a gene which maps to chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome.