CREB3L3 encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. CAMP Responsive Element Binding Protein 3 Like 3 is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.
Human 1, Mouse, Rat
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