CTNNB1,also known as ?-Catenin,is an evolutionarily conserved,multifunctional intracellular protein. CTNNB1 was originally identified in cell adherens junctions (Ajs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the Ajs,CTNNB1 is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of CTNNB1 activity is associated with multiple diseases including cancers. .
Catenin beta Monoclonal Antibody
£192.00 – £399.00 excluding VAT
| Size | 120μL, 200μL |
|---|---|
| Swissprot | P35222, Q02248, Q9WU82 |
| Applications | WB, IHC |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Isotype | IgG |
| Research Areas | Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells |
| Concentration | 420 ?g/mL |
| Storage | Store at -20°C. Avoid freeze / thaw cycles. |
| Immunogen | Recombinant protein corresponding to Mouse ?-catenin |
| Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
| Purification Method | Affinity purification |
| Dilution | WB 1:500-1:1000, IHC 1:100-1:500 |
| Conjugation | Unconjugated |
| Clonality | Monoclonal |
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