Fagus Antibody Services

CaVα2δ2 Rabbit pAb

£118.40£248.00 excluding VAT

SKU FAS-8297-A Category

Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by CACNA2D2 undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in CACNA2D2 are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in CACNA2D2 are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms.

Size

50μL, 100μL

Gene ID

9254

Applications

IHC, WB

Reactivity

Human 1, Mouse, Rat

Host

Rabbit

Isotype
Concentration

1mg/ml

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Dilution
Clonality

Polyclonal

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