Fagus Antibody Services

CD274 Rabbit pAb

£118.40£248.00 excluding VAT

CD274, also commonly referred to as PDL1, is a ligand that binds with the receptor PD1, commonly found on T-cells, and acts to block T-cell activation. PD1 expression has been observed in a variety of cancers including melanoma and non-small cell lung cancer. The interaction of PD1/PDL1 is hypothesized to be a possible mechanism for the tumor to escape immune response. A number of checkpoint blockade inhibitors including pembrolizumab and nivolumab have been developed that target the PD1/PDL1 interaction in order to allow T-cells to recognize tumor cells without being deactivated by the tumor.

Size

50μL, 100μL

Gene ID

29126

Applications

ELISA, IHC

Reactivity

Human 1

Host

Rabbit

Isotype
Concentration

1mg/ml

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Dilution
Clonality

Polyclonal

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