CDCA7 (cell division cycle associated 7) was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of CDCA7 is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
Human 1, Mouse, Rat
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