Fagus Antibody Services

Cleaved PARP Mouse mAb

£118.40£198.40 excluding VAT

SKU FAS-1145-MA Category

Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.

Size

50μL, 100μL

Gene ID

142

Applications

IHC, WB

Reactivity

Human

Host

Mouse

Isotype

IgG1

Concentration

1mg/ml

Storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Dilution

WB 1:2, 000-5, 000  IHC  1:200-500

Clonality

Monoclonal

Related Product