CYP3A5 (Cytochrome P450 Family 3 Subfamily A Member 5) is a Protein Coding gene. Diseases associated with CYP3A5 include Hypertension, Essential and Cyp3a5-Related Altered Drug Metabolism. Among its related pathways are Imipramine/Desipramine Pathway, Pharmacokinetics and Metabolism. CYP3A5 encodes a member of the cytochrome P450 superfamily of enzymes. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. CYP3A5 is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.