The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades.
EGFR Mouse mAb
£118.40 – £198.40 excluding VAT
| Size | 50μL, 100μL |
|---|---|
| Gene ID | 1956 |
| Applications | IF, IHC, IP, WB |
| Reactivity | Human |
| Host | Mouse |
| Isotype | IgG1 |
| Concentration | 1mg/ml |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles. |
| Dilution | WB 1:1, 000-3, 000 IP 1:200 IF 1:100-200 |
| Clonality | Monoclonal |
