KRT81 (Keratin 81) is a Protein Coding gene. Diseases associated with KRT81 include Monilethrix and Hair Disease. Among its related pathways are Keratinization and Developmental Biology. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in KRT81 and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.