MARCH6 encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. MARCH6 (Membrane Associated Ring-CH-Type Finger 6) is a Protein Coding gene. Diseases associated with MARCH6 include Intrahepatic Cholestasis. Among its related pathways are Protein processing in endoplasmic reticulum and Transport to the Golgi and subsequent modification.