Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.
Recombinant Human AgRP/AGRP Protein (Fc Tag)
£576.80 – £721.00 excluding VAT
Size | 50µg |
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Active Protein | |
Activity | |
Protein Construction | A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed with the fused Fc region of human IgG1 at the C-terminus. |
Sequence | Met 1-Thr 132 |
Fusion Tag | C-Fc |
Accession | NP_001129.1 |
Species | Human |
Expressed Host | HEK293 Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 97 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 39 kDa |
AP Mol Mass | 39 kDa |
Formulation | Lyophilized from sterile PBS, pH 7.2 |
Research Areas | Signal Transduction, Cardiovascular, Neuroscience, Cancer, metabolism |
Reconstitution | Please refer to the printed manual for detailed information. |