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Recombinant Human AgRP/AGRP Protein (His Tag)

£576.80 – £721.00 excluding VAT

SKU FAS-031894-P Category Tag

Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

Size

50µg
Active Protein
Activity
Protein Construction

A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed, with a polyhistidine tag at the C-terminus.
Sequence

Met 1-Thr 132
Fusion Tag

C-His
Accession

NP_001129.1
Species

Human
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 90 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

14 kDa
AP Mol Mass

16-19 kDa
Formulation

Lyophilized from sterile PBS, pH 7.2
Research Areas

Signal Transduction, Cardiovascular, Neuroscience, Cancer, metabolism
Reconstitution

Please refer to the printed manual for detailed information.

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