Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1; Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition; SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).
Recombinant Human Alpha-Synuclein/SNCA Protein (Active)
£29.60 – £111.00 excluding VAT
| Size | 10µg, 50µg |
|---|---|
| Active Protein | Active protein |
| Activity | Recombinant Human alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP/Stub1. Aggregation T1/2 time of 70 µM human alpha -Synuclein protein is 1.07h(0.5 mM SDS). |
| Protein Construction | Recombinant Human SLAMF6 is produced by our E.coli expression system and the target gene encoding Met1-Ala140 is expressed. |
| Sequence | Met1-Ala140 |
| Fusion Tag | |
| Accession | P37840 |
| Species | Human |
| Expressed Host | E.coli |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 14.46 kDa |
| AP Mol Mass | 17 kDa |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, PH7.4. |
| Research Areas | Neuroscience |
| Reconstitution | Please refer to the printed manual for detailed information. |
