Fagus Antibody Services

Recombinant Human Arginase-1 Protein (His Tag)

£280.00£479.20 excluding VAT

SKU FAS-500021-P Category Tags , , ,

Arginase 1, also known as liver arginase, is a binuclear manganese metalloenzyme. It is a key enzyme of the urea cycle that catalyses the conversion of L-arginine into L-ornithine and urea, the final cytosolic reaction of urea formation in the mammalian liver. Arginase 1 is abundantly expressed in liver, but it is also expressed in cells and tissues that lack a complete urea cycle, including lung. Arginase is a critical regulator of nitric oxide synthesis and vascular function. It is implicated in a variety of human diseases including vascular disease, pulmonary disease, infectious disease, immune cell function and cancer. In humans, hereditary defects in arginase result in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia.

Size

50µg, 100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the human Arginase-1 (1M-322K) was expressed with a polyhistidine tag at the N-terminus.

Sequence

1M-322K

Fusion Tag

N-His

Accession

P05089

Species

Human

Expressed Host

E.coli

Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

Please contact us for more information.

Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Mol Mass

36.9kDa

AP Mol Mass

38-40kDa

Formulation

Liquid with sterile 25mM Tris-HCl+150mM KCl+1mM DTT+20% glycerol

Research Areas

Signal Transduction, metabolism

Reconstitution

Not Applicable

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