Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
Recombinant Human BCL2L1/Bcl-XL Protein (His Tag)
£220.00 – £525.00 excluding VAT
Size | 10µg, 50µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Recombinant Human BCL2L1 is produced by our E.coli expression system and the target gene encoding Met1-Arg212 is expressed with a 6His tag at the C-terminus. |
Sequence | Met1-Arg212 |
Fusion Tag | C-His |
Accession | Q07817 |
Species | Human |
Expressed Host | E.coli |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass | 24.85 kDa |
AP Mol Mass | 29 kDa |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5. |
Research Areas | Signal Transduction, Cell biology, Cancer, metabolism |
Reconstitution | Not Applicable |
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