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Recombinant Human BCL6/B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx Tag)

£388.80 – £486.00 excluding VAT

SKU FAS-030910-P Category Tag

The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin’s lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

Size

100µg
Active Protein
Activity
Protein Construction

A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.
Sequence

Met 1-Met 150
Fusion Tag

N-His & Trx
Accession

P41182
Species

Human
Expressed Host

E.coli
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 92 % as determined by reducing SDS-PAGE.
Endotoxin

Please contact us for more information.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

34.2 kDa
AP Mol Mass

33 kDa
Formulation

Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0
Research Areas

Cancer, epigenetics and nuclear signal
Reconstitution

Please refer to the printed manual for detailed information.

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