Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).
Recombinant Human BLK Protein (His Tag)
£220.00 – £525.00 excluding VAT
| Size | 10µg, 50µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | Recombinant Human Tyrosine-Protein Kinase BLK is produced by our E.coli expression system and the target gene encoding Gly2-Pro505 is expressed with a 6His tag at the C-terminus. |
| Sequence | Gly2-Pro505 |
| Fusion Tag | C-6His |
| Accession | NP_001706.2 |
| Species | Human |
| Expressed Host | E.coli |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Mol Mass | 58.7 kDa |
| AP Mol Mass | 58.7 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, 1mM DTT, pH 7.4. |
| Research Areas | Cell biology |
| Reconstitution | Not Applicable |
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