Fagus Antibody Services

Recombinant Human BRCA2 Protein (His Tag)

£79.20£612.00 excluding VAT

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Size

20µg, 100µg

Active Protein

Active protein

Activity

Immunogen(E-AB-40288)

Protein Construction

A DNA sequence encoding the Human BRCA2 (P51587-1) (Thr2350-Val2545) was expressed with a polyhistidine tag at the N-terminus.

Sequence

Thr2350-Val2545

Fusion Tag

N-His

Accession

P51587-1

Species

Human

Expressed Host

E.coli

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 85 % as determined by reducing SDS-PAGE.

Endotoxin

Please contact us for more information.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

22.1kDa

AP Mol Mass

25.4kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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