Fagus Antibody Services

Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc-Avi) Biotinylated

£273.60£739.20 excluding VAT

SKU FAS-033997-P Category Tag

Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first, second, or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system, Butyrophilin 2A2 is expressed on thymic epithelial cells, naïve B cells, splenic NK cells, dendritic cells, and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.

Size

20µg, 100µg

Active Protein
Activity
Protein Construction

Biotinylated Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our Mammalian expression system and the target gene encoding Gln33-Val237 is expressed with a Fc, Avi tag at the C-terminus.

Sequence

Gln33-Val237

Fusion Tag

C-Fc-Avi

Accession

Q8WVV5

Species

Human

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

51.5 kDa

AP Mol Mass

55-80 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Research Areas

Cell biology, Cancer, immunology

Reconstitution

Please refer to the printed manual for detailed information.

Related Product