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Recombinant Human CALCB Protein (aa 1-118, Fc Tag)

£684.00 – £855.00 excluding VAT

SKU FAS-030665-P Category Tag

CALCB; also known as CGPR and calcitonin 2; belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin; blood; and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS); of monkeys infected with simian immunodeficiency virus; and of rats subjected to L5/L6 spinal nerve ligation; sciatic nerve chronic constriction; and subcutaneous injection of complete Freund’s adjuvant. Increased CGRP-IL was also detected in epidermal keratinocytes of transgenic mice with keratin-14 promoter driven overexpression of noggin; an antagonist to BMP-4 signaling. CGPR dilates a variety of vessels including the coronary; cerebral and systemic vasculature.

Size

100µg
Active Protein
Activity
Protein Construction

A DNA sequence encoding the human CALCB (P10092) (Met1-Phe118) was fused with Fc region of mouse IgG at the C-terminus.
Sequence

Met 1-Phe118
Fusion Tag

C-Fc
Accession

P10092
Species

Human
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg of the protein as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

36.2 kDa
AP Mol Mass
Formulation

Lyophilized from sterile PBS, pH 7.4
Research Areas

Cardiovascular, Neuroscience
Reconstitution

Please refer to the printed manual for detailed information.

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