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Recombinant Human CD155/PVR/NECL5 Protein (His Tag)(Active)

£220.00 – £525.00 excluding VAT

SKU FAS-033563-P Category Tag

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.

Size

10µg, 50µg
Active Protein

Active protein
Activity

Immobilized Human TIGIT-Fc(Cat: PKSH033510) at 5μg/ml(100 μl/well) can bind Human PVR-His. The ED50 of Human PVR-His is 11.66 ug/ml .
Protein Construction

Recombinant Human NECL5 is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343(Ile340Met) is expressed with a 6His tag at the C-terminus.
Sequence

Trp21-Asn343(Ile340Met)
Fusion Tag

C-His
Accession

P15151
Species

Human
Expressed Host

Human Cells
Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg as determined by the LAL method.
Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Mol Mass

36.13 kDa
AP Mol Mass

58 kDa
Formulation

Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Research Areas

Microbiology
Reconstitution

Not Applicable

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