Fagus Antibody Services

Recombinant Human CD226/DNAM-1 Protein (Fc Tag)(Active)

£73.60£268.00 excluding VAT

Human DNAX accessory molecule 1 (DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain (ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells; CD8+ T cells; and mast cells; dendritic cell maturation; megakaryocyte and activated platelet adhesion to vascular endothelial cells; and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium; interactions mediated by DNAM-1; enable the metastasis of tumor cells to the lung.

Size

10µg, 50µg

Active Protein

Active protein

Activity

Immobilized Human DNAM-1-Fc at 2μg/ml(100 μl/well) can bind Human Nectin-2-6His(Cat: PKSH032913). The ED50 of Human DNAM-1-Fc is 0.79 ug/mL

Protein Construction

Recombinant Human CD226 Antigen is produced by our Mammalian expression system and the target gene encoding Glu19-Asn247 is expressed with a Fc tag at the C-terminus.

Sequence

Glu19-Asn247

Fusion Tag

C-Fc

Accession

Q15762

Species

Human

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

52.8 kDa

AP Mol Mass

72-90 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Research Areas

immunology

Reconstitution

Please refer to the printed manual for detailed information.

Related Product