CD30; also known as TNFRSF8; is a cell membrane protein of the tumor necrosis factor receptor family; which regulates proliferation/apoptosis and antibody responses. CD30 is expressed by activated; but not by resting; T and B cells. Aberrant expression of CD30 by mastocytosis mast cells and interaction with its ligand CD30L (CD153) appears to play an important role in the pathogenesis and clinical presentation of systemic mastocytosis. CD30 has been considered as a specific diagnostic biomarker of anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL). CD30 is also a biomarker used for targeted therapy by an antibody–drug conjugate.
Recombinant Human CD30/TNFRSF8 Protein (His & Avi Tag)
£273.60 – £924.00 excluding VAT
| Size | 20µg, 100µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | Biotinylated Recombinant Human TNFRSF8 is produced by our Mammalianexpression system and the target gene encoding Gln24-Lys265(Met115Thr) is expressed with a 6His; Avitag at the C-terminus. |
| Sequence | Gln24-Lys265(Met115Thr) |
| Fusion Tag | C-His-Avi |
| Accession | P28908 |
| Species | Human |
| Expressed Host | Human Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 41.1 kDa |
| AP Mol Mass | 60-90 kDa |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mMNaCl, pH7.4. |
| Research Areas | Cancer, immunology |
| Reconstitution | Please refer to the printed manual for detailed information. |
Related Product
Related products
-
-
-
Protein
Recombinant ZIKV (strain Zika SPH2015) NS5 protein (His Tag)
£363.20 – £855.00 excluding VAT -
Protein
Recombinant SARS-CoV-2 (2019-nCoV) S protein RBD (C-mFc-6His tag)(Active)
£180.00 – £875.00 excluding VAT -
-
-
-
-
-