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Recombinant Rat JAM-A/F11R Protein (Fc Tag)

£585.60 – £5,875.00 excluding VAT

SKU FAS-030298-P Category Tag

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Size

100µg
Active Protein
Activity
Protein Construction

A DNA sequence encoding the rat F11R () was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Sequence

Met1-Gly238
Fusion Tag

C-Fc
Accession

Q9JHY1
Species

Rat
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 96 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

49.9 kDa
AP Mol Mass

60 kDa
Formulation

Lyophilized from sterile PBS, pH 7.4
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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