CD47(Integrin-Associated Protein;IAP) is a 40 – 60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. The ubiquitously expressed CD47 binds to SIRP family members on macrophages; neutrophils; and T cells. CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the C-terminal cell-binding domain of thrombospondin; and it may play a role in membrane transport and signal transduction. This protein has broad tissue distribution; and is reduced in expression on Rh erythrocytes.
Recombinant Human CD47/IAP Protein (Fc & Avi Tag)
£273.60 – £739.20 excluding VAT
Size | 20µg, 100µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Biotinylated Recombinant Human CD47 is produced by our Mammalianexpression system and the target gene encoding Gln19-Pro139 is expressed with a Fc; Avi tag at the C-terminus. |
Sequence | Gln19-Pro139 |
Fusion Tag | C-Fc-Avi |
Accession | Q08722 |
Species | Human |
Expressed Host | Human Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 42.7 kDa |
AP Mol Mass | 60-70 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4. |
Research Areas | Cancer, immunology |
Reconstitution | Please refer to the printed manual for detailed information. |
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