Fagus Antibody Services

Recombinant Human CD93/C1QR1 Protein (aa 1-580, His Tag)

£585.60£732.00 excluding VAT

CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protein expressed on monocytes; neutrophils; endothelial cells; and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93/C1qR; a receptor expressed during early B-cell development; is reinduced during plasma-cell differentiation. High CD93/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive; memory; and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts/plasma cells; including long-lived plasma cells that showed decreased cell cycle activity; high levels of isotype-switched Ig secretion; and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.

Size

50µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the human CD93 (Q9NPY3) extracellular domain (Met 1-Lys 580) was fused with a polyhistidine tag at the C-terminus.

Sequence

Met 1-Lys 580

Fusion Tag

C-His

Accession

Q9NPY3

Species

Human

Expressed Host

HEK293 Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

59.6 kDa

AP Mol Mass

100 kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas

Cardiovascular, immunology, Stem cells

Reconstitution

Please refer to the printed manual for detailed information.

Related Product