Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome.
Recombinant Human CTNNB1 Protein
£224.00 – £540.00 excluding VAT
Size | 20μg, 100μg |
---|---|
Active Protein | |
Activity | |
Protein Construction | A DNA sequence encoding the Human Human CTNNB1 Protein(P35222)(131-670)was expressed with a polyhistidine tag at the N-terminus. |
Sequence | Met131-Tyr670 |
Fusion Tag | N-His |
Accession | NP_001091679.1 |
Species | Human |
Expressed Host | E.coli |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 85 % as determined by reducing SDS-PAGE. |
Endotoxin | Please contact us for more information. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 59 kDa |
AP Mol Mass | 59 kDa |
Formulation | Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% tween-80. |
Research Areas | Cancer, Cardiovascular, Neuroscience, Signal Transduction |
Reconstitution | Please refer to the printed manual for detailed information. |