Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers; thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt; activin; and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis); abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
Recombinant Human EDAR/DL Protein (Fc Tag)
£388.80 – £486.00 excluding VAT
Size | 100µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | A DNA sequence encoding the human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with the Fc region of human IgG1 at the C-terminus. |
Sequence | Met 1-Ile 189 |
Fusion Tag | C-Fc |
Accession | NP_071731.1 |
Species | Human |
Expressed Host | HEK293 Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 96 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 44.6 kDa |
AP Mol Mass | 52 kDa |
Formulation | Lyophilized from sterile PBS, pH 7.4 |
Research Areas | Signal Transduction, epigenetics and nuclear signal |
Reconstitution | Please refer to the printed manual for detailed information. |
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