Fagus Antibody Services

Recombinant Human EDAR/DL Protein (Fc Tag)

£388.80£486.00 excluding VAT

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers; thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt; activin; and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA); also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis); abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Size

100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the human EDAR (NP_071731.1) extracellular domain (Met 1-Ile 189) was fused with the Fc region of human IgG1 at the C-terminus.

Sequence

Met 1-Ile 189

Fusion Tag

C-Fc

Accession

NP_071731.1

Species

Human

Expressed Host

HEK293 Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 96 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

44.6 kDa

AP Mol Mass

52 kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas

Signal Transduction, epigenetics and nuclear signal

Reconstitution

Please refer to the printed manual for detailed information.

Related Product