Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus; but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26; along with Eotaxin-1 and Eotaxin-2; selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines; CCL26 maps to human chromosome 7q11.2; within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.
Recombinant Human Eotaxin-3/CCL26 Protein (aa 24-94)
£231.20 – £566.00 excluding VAT
Size | 10µg, 50µg |
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Active Protein | |
Activity | |
Protein Construction | Recombinant Human CCL26 is produced by our E.coli expression system and the target gene encoding Thr24-Leu94 is expressed. |
Sequence | Thr24-Leu94 |
Fusion Tag | |
Accession | Q9Y258 |
Species | Human |
Expressed Host | E.coli |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass | 8.53 kDa |
AP Mol Mass | 13 kDa |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris, 1mM EDTA, 20% Glycerol, pH 9.0. |
Research Areas | immunology |
Reconstitution | Not Applicable |