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Recombinant Human ESAM Protein

£585.60 – £732.00 excluding VAT

SKU FAS-031780-P Category Tag

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain; as well as a hydrophobic signal sequence; a single transmembrane region; and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall; possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Size

100µg
Active Protein
Activity
Protein Construction

The mature form of human ESAM (NP_620411.2) extracellular domain (Met 1-Ala 248) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Sequence

Met 1-Ala 248
Fusion Tag
Accession

NP_620411.2
Species

Human
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 92 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

24.5 kDa
AP Mol Mass

40-45 kDa
Formulation

Lyophilized from sterile 100mM NaCl, 50mM Tris, pH 7.5
Research Areas

Signal Transduction, Tags & Cell Markers, Cardiovascular, Cancer
Reconstitution

Please refer to the printed manual for detailed information.

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