Complement factor D; also known as adipsin; is a member of the chymotrypsin family of serine proteases; which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3; which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes; including immunity and inflammation.
Recombinant Human Factor D Protein (His Tag)
£142.40 – £523.00 excluding VAT
| Size | 10µg, 50µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | Recombinant Human Complement factor D is produced by our Mammalian expression system and the target gene encoding Ile26-Ala253 is expressed with a 10His tag at the C-terminus. |
| Sequence | Ile26-Ala253 |
| Fusion Tag | C-10His |
| Accession | P00746 |
| Species | Human |
| Expressed Host | Human Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 25.8 kDa |
| AP Mol Mass | 28 kDa |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH7.5. |
| Research Areas | immunology |
| Reconstitution | Please refer to the printed manual for detailed information. |
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