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Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated

£273.60 – £739.20 excluding VAT

SKU FAS-033906-P Category Tag

FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).

Size

20µg, 100µg
Active Protein
Activity
Protein Construction

Biotinylated Recombinant Human IgG Fc fragment receptor transporter is produced by our Mammalian expression system and the target gene encoding Ala24-Ser297&Ile21-Met119 is expressed with a 6His, Avi tag at the C-terminus.
Sequence

Ala24-Ser297&Ile21-Met119
Fusion Tag

C-6His-Avi
Accession

AAF72596&P61769
Species

Human
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

31.1&13.5 kDa
AP Mol Mass

35&13 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
Research Areas

Cardiovascular, Cancer
Reconstitution

Please refer to the printed manual for detailed information.

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