Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3.
Recombinant Human FGL1 (C-Avi-6His) Biotinylated
£312.00 – £784.00 excluding VAT
Size | 20µg, 100µg |
---|---|
Active Protein | Active protein |
Activity | Immobilized Human LAG-3-Fc(Cat#CU30) at 10μg/ml (100 μl/well) can bind Biotinylated Human FGL1-Avi(Cat#CY21). The ED50 of Human FGL1-Avi (Cat#CY21) is 1908ng/mL. |
Protein Construction | Biotinylated Recombinant Human Fibrinogen-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu23-Ile312 is expressed with a Avi, 6His tag at the C-terminus. |
Sequence | Leu23-Ile312 |
Fusion Tag | C-Avi-6His |
Accession | Q08830 |
Species | Human |
Expressed Host | Human Cells |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
Purity | > 90 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass | 36.6 kDa |
AP Mol Mass | 35 kDa |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 10% Glycerol, 2mM EDTA, pH 8.0. |
Research Areas | Cardiovascular |
Reconstitution | Not Applicable |