Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Recombinant Human ACE2 Protein (Avi-His Tag)
£273.60 – £924.00 excluding VAT
| Size | 20µg, 100µg |
|---|---|
| Active Protein | Active protein |
| Activity | Immobilized 2019-nCoV S1 Protein-Fc(Cat#PKSR030480) at 2μg/ml (100 μl/well) can bind Biotinylated Human ACE-2-Avi-His (Cat#PKSR030493). The ED50 of Biotinylated Human ACE-2-Avi-His (Cat#PKSR030493) is 0.17 ug/ml. |
| Protein Construction | Biotinylated Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Avi, 6His tag at the C-terminus. |
| Sequence | Gln18-Ser740 |
| Fusion Tag | C-Avi-6His |
| Accession | Q9BYF1 |
| Species | Human |
| Expressed Host | Human Cells |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Mol Mass | 86.2 kDa |
| AP Mol Mass | 110-140 kDa |
| Formulation | Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4. |
| Research Areas | Cell biology, Cardiovascular |
| Reconstitution | Not Applicable |
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