X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL; which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci; and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.
Recombinant Human IL-1R9/IL1RAPL2 Protein (His Tag)(Active)
£752.00 – £6,128.00 excluding VAT
| Size | 100µg, 1mg |
|---|---|
| Active Protein | Active protein |
| Activity | Measured by its ability to bind biotinylated human IL1α in functional ELISA. |
| Protein Construction | A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) was expressed; with a C-terminal polyhistidine tag. |
| Sequence | Met 1-Glu 356 |
| Fusion Tag | C-His |
| Accession | NP_059112.1 |
| Species | Human |
| Expressed Host | HEK293 Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 40.7 kDa |
| AP Mol Mass | 50-55 kDa |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Research Areas | Neuroscience |
| Reconstitution | Please refer to the printed manual for detailed information. |
