Fagus Antibody Services

Recombinant Human IL-1RAcP/IL1R3 Protein (His Tag)

£39.20£148.00 excluding VAT

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the interleukin-1 receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-ligand binding accessory component of the receptors for IL1α; IL1βand IL33. IL-1RAcP mediates interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1; TOLLIP; MYD88; and IRAK1 or IRAK2. In addition; IL-1RAcP modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Human IIL-1RAcP is produced by our Mammalian expression system and the target gene encoding Ser21-Gln356 is expressed with a 6His tag at the C-terminus.

Sequence

Ser21-Gln356

Fusion Tag

C-His

Accession

Q9NPH3

Species

Human

Expressed Host

Human Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per μg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

39.75 kDa

AP Mol Mass

67 kDa

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Research Areas

Cardiovascular, immunology

Reconstitution

Please refer to the printed manual for detailed information.

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