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Recombinant Human IL-22BP/IL-22RA2 Protein (His Tag)(Active)

£103.20 – £375.00 excluding VAT

SKU FAS-033384-P Category

Interleukin-22 Receptor Subunit α-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Size

10µg, 50µg
Active Protein

Active protein
Activity

Measured by its ability to inhibit IL-22-induced IL-10 secretion by COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is typically 113.2 ng/ml in the presence of 500 ng/mL of Recombinant Human IL-22.
Protein Construction

Recombinant Human Interleukin-22 receptor subunit alpha-2/Interleukin-22 Binding Protein is produced by our Mammalian expression system and the target gene encoding Thr22-Pro231 is expressed with a 6His tag at the C-terminus.
Sequence

Thr 22-Pro231
Fusion Tag

C-6His
Accession

Q969J5-2
Species

Human
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 95 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

25.7 kDa
AP Mol Mass

44 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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