Fagus Antibody Services

Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)

£585.60£732.00 excluding VAT

SKU FAS-030736-P Category Tag

R-spondin-2; also known as RSPO2; synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway; possibly via a direct interaction with Wnt proteins; and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells; consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice; they exhibited greater metastatic activity than cells derived from Wnt1 tumors.



Active Protein

Active protein


Measured by its binding ability in a functional ELISA. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4.5-10.4ng/mL.

Protein Construction

A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.


Met 1-Gly289

Fusion Tag






Expressed Host

HEK293 Cells


This product is provided as lyophilized powder which is shipped with ice packs.


> 85 % as determined by reducing SDS-PAGE.


< 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

56.9 kDa

AP Mol Mass

67 kDa


Lyophilized from sterile PBS, pH 7.4

Research Areas

Cell biology, Cancer, immunology


Please refer to the printed manual for detailed information.

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