Fagus Antibody Services

Recombinant Human IL17BR/IL17RB Protein (Fc Tag)(Active)

£585.60£732.00 excluding VAT

SKU FAS-030736-P Category Tag

R-spondin-2; also known as RSPO2; synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway; possibly via a direct interaction with Wnt proteins; and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells; consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice; they exhibited greater metastatic activity than cells derived from Wnt1 tumors.

Size

100µg

Active Protein

Active protein

Activity

Measured by its binding ability in a functional ELISA. Immobilized human IL17BR-Fc at 10μg/mL (100μL/well) can bind biotinylated human Fc-IL25.The EC50 of human Fc-IL25 is 4.5-10.4ng/mL.

Protein Construction

A DNA sequence encoding the human IL17BR (NP_061195.2) (Met1-Gly289) was expressed with the Fc region of human IgG1 at the C-terminus.

Sequence

Met 1-Gly289

Fusion Tag

C-Fc

Accession

NP_061195.2

Species

Human

Expressed Host

HEK293 Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 85 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg of the protein as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

56.9 kDa

AP Mol Mass

67 kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas

Cell biology, Cancer, immunology

Reconstitution

Please refer to the printed manual for detailed information.

Related Product