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Recombinant Human IL17RA Protein (His Tag)(Active)

£585.60 – £732.00 excluding VAT

SKU FAS-031368-P Category Tag

Interleukin-17 receptor (IL-17R); also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217); is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections; selective against Candida. It is characterized by persistent and/or recurrent infections of the skin; nails and mucous membranes caused by organisms of the genus Candida; mainly Candida albicans.

Size

100µg
Active Protein

Active protein
Activity

1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL17A at 2 μg/ml (100 μl/well) can bind biotinylated human IL17RA with a linear range of 1.28-32 ng/ml.2. Measured by its ability to inhibit IL-17-induced IL-6 secretion by HFF human foreskin fibroblast cells. The ED50 for this effect is typically 0.03-0.12 μg/mL.
Protein Construction

A DNA sequence encoding the extracellular domain of human IL17RA (NP_055154.3) (Met 1-Trp 320) was fused with a polyhistidine tag at the C-terminus.
Sequence

Met 1-Trp 320
Fusion Tag

C-His
Accession

NP_055154.3
Species

Human
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 97 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg of the protein as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

35 kDa
AP Mol Mass
Formulation

Lyophilized from sterile PBS, pH 7.4
Research Areas

immunology
Reconstitution

Please refer to the printed manual for detailed information.

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