IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Recombinant Human IL1RL1/ST2 Protein (His Tag)(Active)
£388.80 – £486.00 excluding VAT
Size | 100µg |
---|---|
Active Protein | Active protein |
Activity | 1.Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind biotinylated human IL1RL1 with a linear range of 0.16-8 μg/ml. |
Protein Construction | A DNA sequence encoding the human IL1RL1 isoform 2 (NP_003847.2) (Met 1-Phe 328) was expressed, fused with a polyhistidine tag at the C-terminus. |
Sequence | Met 1-Phe 328 |
Fusion Tag | C-His |
Accession | NP_003847.2 |
Species | Human |
Expressed Host | HEK293 Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 36.5 kDa |
AP Mol Mass | 55-60 kDa |
Formulation | Lyophilized from sterile PBS, pH 7.4 |
Research Areas | Cardiovascular, immunology |
Reconstitution | Please refer to the printed manual for detailed information. |
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