Fagus Antibody Services

Recombinant Human IL1RL1/ST2 Protein (His Tag)(Active)

£388.80£486.00 excluding VAT

IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines.



Active Protein

Active protein


1.Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind biotinylated human IL1RL1 with a linear range of 0.16-8 μg/ml.

Protein Construction

A DNA sequence encoding the human IL1RL1 isoform 2 (NP_003847.2) (Met 1-Phe 328) was expressed, fused with a polyhistidine tag at the C-terminus.


Met 1-Phe 328

Fusion Tag






Expressed Host

HEK293 Cells


This product is provided as lyophilized powder which is shipped with ice packs.


> 95 % as determined by reducing SDS-PAGE.


< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

36.5 kDa

AP Mol Mass

55-60 kDa


Lyophilized from sterile PBS, pH 7.4

Research Areas

Cardiovascular, immunology


Please refer to the printed manual for detailed information.

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