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Recombinant Human Interleukin-35/IL-35 (C-Fc)

£140.80 – £369.60 excluding VAT

SKU FAS-033974-P Category Tag

Interleukin-35 is a newest and potent suppressive cytokine of the IL-12 family. Unlike other members of the IL-12 family which are produced mainly by antigen-presenting cells (APCs), IL-35 has been identified as a potentially immunosuppressive cytokine primarily produced by regulatory T (Treg) cells, and to a lesser extent by activated dendritic cells and macrophages. IL-35 is composed of the IL-12 p35 subunit and the IL-27 Epstein–Barr virus-induced protein 3 (EBI3) subunit. IL-35 plays an important role in many disease models and has been recently shown to have additional functions aside from inhibition of proliferation, including inducing its own expression in non-Treg cells.

Size

10µg, 50µg
Active Protein
Activity
Protein Construction

Recombinant Human Interleukin-35 is produced by our Mammalian expression system and the target gene encoding Arg23-Ser219&Arg21-Lys229 is expressed with a Fc tag at the C-terminus.
Sequence

Arg23-Ser219&Arg21-Lys229
Fusion Tag

C-Fc
Accession

P29459&Q14213
Species

Human
Expressed Host

Human Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

>90% as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

73.7 kDa
AP Mol Mass

80-120 kDa
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Research Areas

Cancer, immunology
Reconstitution

Please refer to the printed manual for detailed information.

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