Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule; LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Recombinant Human LAG3/CD223 Protein (His Tag)(Active)
£88.80 – £297.00 excluding VAT
Size | 10µg, 50µg |
---|---|
Active Protein | Active protein |
Activity | Immobilized Human LAG-3-His at 5μg/ml(100 μl/well) can bind Human FGL1-mFc(Cat: PKSH033679). The ED50 of Human LAG-3-His is 29 ng/ml. |
Protein Construction | Recombinant Human LAG3 Protein is produced by our Mammalian expression system and the target gene encoding Leu23-Leu450 is expressed with a 6His tag at the C-terminus. |
Sequence | Leu23-Leu450 |
Fusion Tag | C-His |
Accession | P18627 |
Species | Human |
Expressed Host | Human Cells |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 47.2 kDa |
AP Mol Mass | 55-65 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, 2mMEDTA, pH7.4. |
Research Areas | immunology |
Reconstitution | Please refer to the printed manual for detailed information. |
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