The leukocyte immunoglobulin-like receptor (LILR) B4 belongs to a family of cell surface receptors that possesses cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB4 is believed to down-regulate activation signals mediated by non-receptor tyrosine kinase cascades through the recruitment of SHP-1. LILRB4 is associated with the pathological processes of various inflammatory diseases.The LILRB4 is a central inhibitory receptor in uterine dendritic cells (uDCs) that plays essential immune-regulatory roles at the maternal-fetal interface.
Recombinant Human LILRB4/CD85k/ILT3 Protein (aa 1-257, Fc Tag)
£884.00 – £8,835.00 excluding VAT
| Size | 100µg, 1mg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | A DNA sequence encoding the human LILRB4 (NP_001265356.2) (Met1-His257) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Sequence | Met 1-His257 |
| Fusion Tag | C-Fc |
| Accession | NP_001265356.2 |
| Species | Human |
| Expressed Host | HEK293 Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg of the protein as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 52.8 kDa |
| AP Mol Mass | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Research Areas | Cardiovascular, epigenetics and nuclear signal, immunology |
| Reconstitution | Please refer to the printed manual for detailed information. |
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