Fagus Antibody Services

Recombinant Human Merlin/NF2 protein (His Tag)

£79.20£799.20 excluding VAT

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Size

20µg, 100µg

Active Protein

Active protein

Activity

Immunogen(E-AB-40336)

Protein Construction

A DNA sequence encoding the Human Merlin/NF2 (P35240-1) (1M-595L) was expressed with a polyhistidine tag at the N-terminus.

Sequence

1M-595L

Fusion Tag

N-His

Accession

P35240-1

Species

Human

Expressed Host

E.coli

Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity

> 90 % as determined by reducing SDS-PAGE.

Endotoxin

Please contact us for more information.

Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Mol Mass

69.7kDa

AP Mol Mass

68-71kDa

Formulation

Supplied as sterile Tris, EDTA, PH 8.0.

Research Areas
Reconstitution

Not Applicable

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