LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61 and MESDC2, is a member of the MESD family. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity resides in the N- and C-terminal unstructured regions. MESDC2 acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway. MESDC2 is essential for specification of embryonic polarity and mesoderm induction.
Recombinant Human MESDC2/MESD Protein (His Tag)
£585.60 – £732.00 excluding VAT
| Size | 100µg |
|---|---|
| Active Protein | |
| Activity | |
| Protein Construction | A DNA sequence encoding the human MESDC2 (NP_055969.1) (Ala 34-Lys 230) was fused with a signal peptide at the N-terminus and a polyhistidine tag at the C-terminus. |
| Sequence | Ala 34-Lys 230 |
| Fusion Tag | C-His |
| Accession | NP_055969.1 |
| Species | Human |
| Expressed Host | HEK293 Cells |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
| Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Mol Mass | 23.6 kDa |
| AP Mol Mass | 27 kDa |
| Formulation | Lyophilized from sterile PBS, pH 7.4 |
| Research Areas | Developmental Biology, Stem cells |
| Reconstitution | Please refer to the printed manual for detailed information. |
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