Fagus Antibody Services

Recombinant Human Mesothelin/MSLN Protein (aa 296-580, Fc Tag)

£585.60£732.00 excluding VAT

Megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised by several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells; mesotheliomas; and ovarian cancer; but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas; ovarian cancers; and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Size

100µg

Active Protein
Activity
Protein Construction

A DNA sequence encoding the human MSLN (Q13421-2) (Glu296-Gly580) was expressed;with the fused Fc region of human IgG1 at the N-terminus.

Sequence

Glu296-Gly580

Fusion Tag

N-Fc

Accession

Q13421-2

Species

Human

Expressed Host

HEK293 Cells

Shipping

This product is provided as lyophilized powder which is shipped with ice packs.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Mol Mass

60.7 kDa

AP Mol Mass

65 kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Research Areas
Reconstitution

Please refer to the printed manual for detailed information.

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