Fagus Antibody Services

Recombinant Human PGD2 Synthase/PTGDS Protein (His Tag)

£220.00£525.00 excluding VAT

SKU FAS-030653-P Category

Prostaglandin-H2 D-Isomerase (PTGDS) belongs to the Lipocalin family of calycin superfamily. PTGDS is preferentially expressed in the brain. PTGDS catalyzes the conversion of PGH2 to PGD2; a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. PTGDS is involved in a variety of CNS functions; such as sedation; REM sleep and PGE2-induced allodynia; and may have an anti-apoptotic role in oligodendrocytes. PTGDS binds small non-substrate lipophilic molecules and may act as a scavenger for harmful hydrophopic molecules and a secretory retinoid and thyroid hormone transporter. It possibly participates in development and maintenance of the blood-brain; blood-retina; blood-aqueous humor; blood-testis barrier; the central nervous system and male reproductive system.

Size

10µg, 50µg

Active Protein
Activity
Protein Construction

Recombinant Human Prostaglandin-D2 Synthase is produced by our Mammalian expression system and the target gene encoding Ala23-Gln190 is expressed with a 6His tag at the C-terminus.

Sequence

Ala23-Gln190

Fusion Tag

C-6His

Accession

P41222

Species

Human

Expressed Host

Human Cells

Shipping

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity

> 95 % as determined by reducing SDS-PAGE.

Endotoxin

< 1.0 EU per µg as determined by the LAL method.

Stability and Storage

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Mol Mass

19.7 kDa

AP Mol Mass

20-27 kDa

Formulation

Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 10%Glycerol, pH7.5.

Research Areas

Signal Transduction

Reconstitution

Not Applicable

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