Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM). Resistin has been shown to cause “high levels of ‘bad’ cholesterol (low-density lipoprotein or LDL); increasing the risk of heart disease; resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. Potentially links obesity to diabetes.
Recombinant Human Resistin Protein (His Tag)
£93.60 – £339.00 excluding VAT
Size | 10µg, 50µg |
---|---|
Active Protein | |
Activity | |
Protein Construction | Recombinant Human Adipose tissue-specific secretory factor is produced by our E.coli expression system and the target gene encoding Lys19-Pro108 is expressed with a 6His tag at the C-terminus. |
Sequence | Lys19-Pro108 |
Fusion Tag | C-6His |
Accession | NP_065148.1 |
Species | Human |
Expressed Host | E.coli |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Mol Mass | 10.6 kDa |
AP Mol Mass | 10-14 kDa |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Acetic acid, pH 3.0. |
Research Areas | Signal Transduction, Cardiovascular, metabolism |
Reconstitution | Please refer to the printed manual for detailed information. |
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