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Recombinant Human/Rhesus HER4/ErbB4 Protein (Fc Tag)(Active)

£585.60 – £732.00 excluding VAT

SKU FAS-031650-P Category Tag

ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains; a transmembrane domain; a tyrosine kinase domain; a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain; heart; kidney; in addition to skeletal muscle; parathyroid; cerebellum; pituitary; spleen; testis and breast. And lower levels in thymus; lung; salivary gland; and pancreas. It specifically binds to and is activated by neuregulins; NRG-2; NRG-3; heparin-binding EGF-like growth factor; betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart; the central nervous system and the mammary gland; gene transcription; cell proliferation; differentiation; migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development; and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system; especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation; induction of milk proteins and lactation.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Size

100µg
Active Protein

Active protein
Activity

1. Measured by its ability to bind biotinylated human Fc-NRG1 (isoform Beta1) in a functional ELISA.2. Measured by its ability to bind biotinylated human NRG1 (isoform Beta1) in a functional ELISA.3. Measured by its ability to bind biotinylated human NRG1 (aa 2-246)-Fc in a functional ELISA.
Protein Construction

A DNA sequence encoding the human ERBB4 (NP_005226.1) (Met1-Arg649) was expressed; fused with the Fc region of human IgG1 at the C-terminus.Human and Rhesus ERBB4 sequences are identical.
Sequence

Met 1-Arg649
Fusion Tag

C-Fc
Accession

NP_005226.1
Species

Human
Expressed Host

HEK293 Cells
Shipping

This product is provided as lyophilized powder which is shipped with ice packs.
Purity

> 85 % as determined by reducing SDS-PAGE.
Endotoxin

< 1.0 EU per µg as determined by the LAL method.
Stability and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Mol Mass

96.6 kDa
AP Mol Mass

117 kDa
Formulation

Lyophilized from sterile PBS, pH7.4
Research Areas

Signal Transduction, Tags & Cell Markers, Cancer, immunology
Reconstitution

Please refer to the printed manual for detailed information.

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